The Double-Blind Placebo Run In: To Be or Not To Be?

In episode seven of our "Clinical Viewpoints" video series of, Dr. Steve Targum, an experienced CNS researcher, discusses the complexities of placebo responses in clinical trials.

Highlighting the challenges of signal detection amidst higher-than-anticipated placebo effects, he explores the efficacy of double-blind placebo run-in designs. Dr. Targum emphasizes the need for systematic approaches to manage placebo responses, citing examples from his research.

He underscores the design's potential to enhance trial outcomes by identifying and managing early responders effectively, despite industry hesitations due to conservatism and cost concerns.