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PROMIS CAT

Advance your patient-focused clinical development with state-of-the-science computerized adaptive testing

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Core Capabilities

Our solution leverages the item response theory statistical model developed by National Institutes of Health to determine the optimal sequence of questions for each patient, and to best estimate the concept of interest for more than twenty domains including anxiety, depression, fatigue, sleep disturbance, pain interference, physical function, and social function. Implement PROMIS CAT alongside traditional PROMs, all within our convenient, industry-leading TrialMax eCOA application.

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Precise Measurement

Capture accurate data for concepts of interest like physical function with adaptive testing

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Reduce Patient Burden

Get reliable results with fewer questions through focused item selection

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Seamless Integration

Enable efficient completion of both PROMIS CAT and traditional PROMs through a single application

Built for Your Clinical Trial Success

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Fully Authorized

Northwestern University PROMIS system license-holder approved

Thoroughly validated

Comprehensive validation across therapeutic areas

Global Ready

Available in multiple languages including English, French, German, Italian, and more

Rapid Setup

Our library version enables quick implementation in your existing studies

Over 20 Measurement Domains Available Including:

Anxiety

Depression

Fatigue

Sleep disturbance

Pain interference

Cognitive function

Physical function

Social function

PROMIS measures were developed using state-of-the-science methods, leveraging the item response theory statistical model, to efficiently measure specific health domains." "By presenting only the most informative questions [items], we can reduce the burden of completion for patients while preserving precise PRO scores."

Executive Director at the Northwestern University Center on Outcomes Research and Education (NUCORE) Michelle Langer, PhD
POWERFUL FEATURES

PROMIS CAT Benefits for Your Clinical Trials

Get precise measurements with fewer questions, reducing patient burden 

Streamline data collection with computerized adaptive testing alongside traditional PROMs

Deploy rapidly with a fully validated, multi-language solution 

Scale confidently with global implementation support

Optimize your measurement strategy with guidance from eCOA scientific experts

How PROMIS CAT Works

Rather than delivering a static questionnaire, PROMIS CAT uses a statistical model (based on Item Response Theory) to select questions based on a patient’s responses to previous questions. This proven computerized adaptive testing approach: 

  • Dynamically selects optimal questions based on previous responses
  • Delivers precise measurements with fewer items
  • Maintains high accuracy across severity ranges
  • Completes testing when desired precision is achieved
Technical Capabilities:
  • Real-time adaptive question selection
  • Secure, validated scoring engine
  • Immediate results reporting
  • Seamless incorporation with traditional PROMs through Signant’s leading TrialMax eCOA solution
DOWNLOAD TECHNICAL WHITEPAPER FOR DETAILS

Explore PROMIS CAT Resources

Whitepaper

Computerized Adaptive Tests Using PROMIS CAT | Technical implementation overview and regulatory considerations

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Press Release

Signant's Novel Electronic PROMIS CAT Assessment Enhances Patient-Centric Drug Development – Latest advances in adaptive testing technology 

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Brochure

Signant SmartSignals eCOA: PROMIS CAT | Quick guide to features and capabilities


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FAQs

What is PROMIS CAT and how does it differ from traditional ePRO?

PROMIS CAT (Patient-Reported Outcome Measure Information System Computerized Adaptive Testing) is a dynamic assessment approach that differs from traditional ePRO questionnaires in how it collects patient data. While traditional ePROs use a fixed set of questions, PROMIS CAT employs an adaptive model that selects questions based on previous responses. This smart questioning system allows it to gather precise measurements with fewer questions, reducing the burden on patients while maintaining measurement accuracy. For more detailed information about CAT performance and implementation, please refer to our comprehensive white paper.

How does PROMIS CAT reduce patient burden?

PROMIS CAT reduces patient burden in several ways:

  • It uses dynamic question selection instead of requiring patients to complete a fixed set of questions
  • The system intelligently chooses the most informative questions based on previous responses
  • It can achieve the same measurement precision as traditional questionnaires with fewer items
  • Patients only answer questions that are most relevant to their specific situation
  • The adaptive approach eliminates unnecessary questions while maintaining scientific rigor

In which therapeutic areas can PROMIS CAT be implemented?

The concepts of interest measured by PROMIS CAT are relevant to many therapeutic areas. Measurement domains include:

  • Anxiety
  • Depression
  • Fatigue
  • Sleep disturbance
  • Pain interference
  • Cognitive function
  • Physical function
  • Social function.

…and more.