Contact us today to engage with our experts and optimize your study's journey from design through regulatory submission, ensuring the highest standards of clinical evidence generation
Meet the Experts
At Signant Health, we combine our technology with robust clinical, scientific, and regulatory expertise to guide your study from design to regulatory submission, ensuring the generation of clinical evidence of the highest quality and integrity.

With more than 50 full-time, in-house experts, we are prepared to advise on all areas of eCOA science and best practice including:
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Dawie Wessels, MD
CHIEF MEDICAL OFFICER

DAVID DANIEL, MD
EXECUTIVE ADVISOR
SCHIZOPHRENIA

GARY SACHS, MD
CLINICAL VICE PRESIDENT

JOAN BUSNER, PhD
CLINCIAL VICE PRESIDENT

LEW FREDANE, MD
CLINICAL VICE PRESIDENT

DAVID MILLER, MD, MA
CLINICAL VICE PRESIDENT

STEPHAN BART, SR MD CPI
EXECUTIVE ADVISOR

ALAN KOTT, MUDr
CLINICAL VICE PRESIDENT
& PRACTICE LEAD
DATA ANALYTICS

TODD EVERHART, MD
CLINICAL VICE PRESIDENT
INTERNAL MEDICINE

BILL BYROM, PhD
VICE PRESIDENT
PRODUCT INTELLIGENCE & POSITIONING

ELIAS KETIAR, MD, MRCP
CLINICAL VICE PRESIDENT

GRETA MARIE VAN SCHOOR, PhD
SENIOR CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE

BRANDEN KUSANTO, PhD
SENIOR CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE

LAUREN CROOKS, MSc
CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE

VIANI FIGUEROA VAZQUEZ, PhD
CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE

Juliet Brown, PhD
CLINICAL DIRECTOR
SCIENCE & MEDICINE

RACHEL BERMAN, PHD
ASSOCIATE DIRECTOR
SCIENCE & MEDICINE

Marcela Roy, MA
EXECUTIVE DIRECTOR
SCIENCE & MEDICINE

Erica Appleman, PhD
CLINICAL SCIENTIST

Jessica Stenclik,
PhD, ABPP-CN
SENIOR CLINICAL SCIENTIST

Marta Pereira, PhD
CLINICAL SCIENTIST

Sayaka Machizawa
ASSOCIATE DIRECTOR,
SCIENCE & MEDICINE, APAC

Margot Oakley, MSN
DIRECTOR CLINICAL SCIENCE

Christopher Murphy, PhD
ASSOCIATE DIRECTOR,
CLINICAL SCIENCE PRINCIPAL,
BDA SPECIALIST

Dawie Wessels, MD
CHIEF MEDICAL OFFICER
As Chief Medical Officer of Signant Health, Dawie’s deep expertise across multiple therapeutic areas, multinational development leadership, and experience in associated commercial growth supports the expanding impact of the Signant Science and Medical team. With over twenty years' experience combining medicine and business, Dawie oversees Signant's scientific and operational strategies.

DAVID DANIEL, MD
EXECUTIVE ADVISOR
SCHIZOPHRENIA
Dr. Daniel has over 25 years of experience overseeing rater training and data quality management programs in various settings. He has supervised countless clinical trials for schizophrenia and bipolar disorder. In addition to his work with Signant, David serves as Clinical Professor of Psychiatry at George Washington University.

GARY SACHS, MD
CLINICAL VICE PRESIDENT
Dr. Sachs is the Therapeutic Area Leader in bipolar disease and mood disorders at Signant. He lends his extensive experience in rater training and the methodologies of mood and anxiety disorder research to support studies.

JOAN BUSNER, PhD
CLINCIAL VICE PRESIDENT
Dr. Busner has over 35 years of experience as an academic psychiatric researcher and psychopharmacology principal investigator, and founded and directed two university psychiatric clinical trials units. Dr. Busner served continuously on University Institutional Review Boards for 20 years. At Signant she has scientific and clinical responsibility for studies in mood, anxiety, pediatrics, and rare/orphan diseases.

LEW FREDANE, MD
CLINICAL VICE PRESIDENT
Dr. Fredane serves as the Therapeutic Area Leader for neurology, overseeing Signant’s eCOA, rater training, and quality assurance work. He has experience as a practicing neurologist, clinical assistant professor, and in the drug development for over 15 years.

DAVID MILLER, MD, MA
CLINICAL VICE PRESIDENT
Dr. Miller is a geriatric psychiatrist by training. He has over 25 years of experience in patient care, clinical research, teaching, and even served as a principal investigator for dementia studies. David currently serves as the Chair of the Alzheimer’s Association Research Roundtable.

STEPHAN BART, SR MD CPI
EXECUTIVE ADVISOR
Dr. Bart is both Board certified and a Certified Physician Investigator with a broad therapeutic scope including successful completion of more than 450 domestic and international phase 1 through 3 human clinical trials. He has maintained a successful private practice, held faculty positions at Penn State University and the University of Maryland Medical Center, as well as published many articles in prestigious peer reviewed journals.

ALAN KOTT, MUDr
CLINICAL VICE PRESIDENT
& PRACTICE LEAD
DATA ANALYTICS
Dr. Kott is based in Signant’s Prague office and until recently was Senior Clinical Manager for Europe. Having led the development of the Data Analytics Program for Bracket, he has overseen the design and reporting of data analytics in multiple large schizophrenia studies. For the past seven years, he has also provided training to investigators as an Expert Trainer.

TODD EVERHART, MD
CLINICAL VICE PRESIDENT
INTERNAL MEDICINE
Dr. Everhart is an innovator, educator, and leader in the pharmaceutical and biotechnology industries with over 25 years of experience in the practice of medicine and over 14 years of experience in clinical research. Board-certified in Internal Medicine and a Fellow of the American College of Physicians, he is one of Signant Health’s experts in decentralized trials, rater training, blinded data analytics, and placebo response mitigation.

BILL BYROM, PhD
VICE PRESIDENT
PRODUCT INTELLIGENCE & POSITIONING
Dr. Byrom has worked in the pharmaceutical industry for 30 years. He has authored over 70 publications and two industry textbooks on electronic patient-reported outcomes (ePRO). His recent scientific work includes the use of wearable technology and bring-your-own-device (BYOD) eCOA in clinical trials.

ELIAS KETIAR, MD, MRCP
CLINICAL VICE PRESIDENT
Dr. Elias Ketiar serves as the Clinical Vice President, Science & Medicine, at Signant Health. Dr. Ketiar draws on his wealth of more than 20 years of academic and clinical experience to advise on clinical trial design, execution, and governance.

GRETA MARIE VAN SCHOOR, PhD
SENIOR CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE
Greta is a Senior Clinical Scientist, providing scientific expertise and guidance relating to the implementation of electronic clinical outcome assessments (eCOAs), with a special focus on eDiary design and accessibility of eCOA best practices. She completed her PhD in Physiological Sciences at Stellenbosch University, which focused on the bacterial and inflammatory involvement in colorectal carcinogenesis, and has 3+ years’ experience in the clinical research industry.

BRANDEN KUSANTO, PhD
SENIOR CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE
Dr. Kusanto studied bioengineering at Oregon State University before completing his PhD in platelet biology at Hull York Medical School. At Signant, he specializes in eCOA, eConsent, and multiple therapeutic areas like, dermatology, gastroenterology, pediatrics, and rare diseases.

LAUREN CROOKS, MSc
CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE
Lauren has comprehensive cross-functional experience within the life sciences and information technology sectors. At Signant, she combines this experience to provide scientific consultation and support to clients on the implementation of eCOA to optimize patient care and outcomes in clinical trials. She has supported eCOA projects across multiple therapeutic areas, including dermatology and neurology, with a current focus on respiratory diseases.

VIANI FIGUEROA VAZQUEZ, PhD
CLINICAL SCIENTIST
DIGITAL HEALTH & eCOA SCIENCE
Dr. Figueroa is a Clinical Scientist with the eCOA Science Team, where she leverages her extensive expertise in electronic Clinical Outcome Assessments (eCOA) across diverse therapeutic areas, including oncology, dermatology, and infectious diseases. With over a decade of translational research experience, Dr. Figueroa is dedicated to advancing the field of clinical trials and improving patient outcomes through innovative methodologies and strategic insights.

Juliet Brown, PhD
CLINICAL DIRECTOR
SCIENCE & MEDICINE
Juliet Brown, Clinical Director, Science & Medicine, is one of Signant Health’s Clinical Thought Leaders. Her specialties are evaluation and treatment in MDD, Bipolar Disorder, Anxiety Disorders, Psychotic Spectrum Disorders, and Substance Use Disorders, as well as Cognitive Behavioral Psychotherapy.

RACHEL BERMAN, PHD
ASSOCIATE DIRECTOR
SCIENCE & MEDICINE
Dr. Berman brings two decades of neuropsychology experience to Signant Health, including clinical science working differential diagnostic services and geriatrics. Specializing in psychiatric and neurological disorders like schizophrenia, bipolar disorder, and behavioral /neuropsychiatric symptoms in dementia, Rachel supports sponsors and CROs running trials in these and other CNS indications.

Marcela Roy, MA
EXECUTIVE DIRECTOR
SCIENCE & MEDICINE
Marcela Roy, MA, ACC serves as Executive Director of Clinical Science & Medicine, bringing over 20 years of clinical and research expertise to her role. She provides strategic leadership across CNS and non-CNS therapeutic areas, with particular expertise in psychedelic research and central ratings data quality monitoring methodologies.

Erica Appleman, PhD
CLINICAL SCIENTIST
Erica Appleman, Ph.D. is a licensed psychologist and Clinical Scientist at Signant Health. She completed her Ph.D. in Clinical Psychology at Boston University and a postdoctoral fellowship in Clinical Neuropsychology. Her clinical expertise includes neuropsychological assessment of adults presenting with a wide variety of neurological, neurodevelopmental, and neuropsychiatric conditions.

Jessica Stenclik,
PhD, ABPP-CN
SENIOR CLINICAL SCIENTIST

Marta Pereira, PhD
CLINICAL SCIENTIST
Marta Pereira studied at the University of Porto where she also graduated in Neuropsychology with a MSc degree. Later, she received her PhD degree in Neurosciences from the University of Sao Paulo. Prior to joining SH, Dr. Marta Pereira was part of the Nuffield Department of Clinical Neurosciences at the University of Oxford, where she worked with digital health tools / wearables in Parkinsonian syndromes.

Sayaka Machizawa
ASSOCIATE DIRECTOR,
SCIENCE & MEDICINE, APAC
Sayaka Machizawa, Psy.D. is a neuropsychologist with 18 years of experience in neurodegenerative diseases. She serves as the Associate Director-APAC Lead supporting large-scale global clinical trials on various indications including but not limited to Alzheimer’s disease, Parkinson’s disease, schizophrenia, major depressive disorder, and rare diseases. She is fluent in Japanese and English and has delivered rater training at numerous Investigator Meetings.

Margot Oakley, MSN
DIRECTOR CLINICAL SCIENCE
Margot is a Masters RN with extensive clinical background that include many areas in the medical field and child and adult Psychiatry. She spent years in the acute hospital setting working in a diverse group of settings.

Christopher Murphy, PhD
ASSOCIATE DIRECTOR,
CLINICAL SCIENCE PRINCIPAL,
BDA SPECIALIST
Christopher Murphy, PhD is Associate Director and Clinical Science Principal at Signant Health, with over 25 years of experience in academic and industry-supported CNS research and trials. Prior to Signant, he was on faculty of Weill Cornell Medical College and served as an Attending Psychologist at New York Presbyterian Hospital.