Early Score Fluctuation and Placebo Response in MDD Study

Early score fluctuations during placebo-controlled MDD trials can undermine baseline reliability and skew study outcomes.

In this article, the authors explore a phase II trial of MSI-195 in MDD subjects, revealing how early fluctuations in scores during the placebo lead-in period impacted placebo response rates.

Discover how these findings suggest that anticipating and managing early responses may lead to more accurate outcome data, ultimately improving signal detection.

Read the full article to learn how managing early fluctuations could improve the reliability of MDD trial results.

This article originally appeared in the Journal of Psychiatric Research by authors Steven D. Targum, Beth R. Cameron, Ludvina Ferreira, and I. David MacDonald.