Baseline Score Inflation: Detection, Impact, and Mitigation 

Many CNS clinical trials use clinician ratings to support important study endpoints.

When ratings are also used as eligibility criteria, this can lead to greater apparent placebo response due to baseline score inflation, and this increases the difficulty in detecting treatment-related effects.

In episode six of our "Clinical Viewpoints" video series, Gary Sachs, MD, Clinical Vice President, Bipolar Disease and Mood Disorders, and Alan Kott, MUDr, Practice Lead, Data Analytics, explore approaches on how to detect and how to mitigate baseline score inflation in CNS trials.