Case Study
How Central Review and Rater Training Optimized Endpoint Quality in 5 MDD Trials
Discover how Signant’s Central Rating services enhanced accuracy in five major depressive disorder trials.
Ensuring Endpoint Reliability in Movement Disorder Trials
Signant Health
Jan 10, 2023
Signant's Rater Training and Central Rating services played a key role in a sponsor’s movement disorder trial by optimizing signal detection of a primary endpoint.
This endpoint was measured using clinician ratings of abnormal, involuntary movements in patients with tardive dyskinesia.
Our solutions and services helped investigators deliver a consistent, standardized set of tests for the Abnormal Involuntary Movement Scale (AIMS) by:
- Training and calibrating raters to ensure accurate, consistent COA administration and scoring
- Conducting site-independent, blinded ratings to assess the change in AIMS score from baseline to week 12 to ensure accuracy
Read our case study for more details.