Ensuring Endpoint Reliability in Movement Disorder Trials

Signant's Rater Training and Central Rating services played a key role in a sponsor’s movement disorder trial by optimizing signal detection of a primary endpoint.

This endpoint was measured using clinician ratings of abnormal, involuntary movements in patients with tardive dyskinesia.

Our solutions and services helped investigators deliver a consistent, standardized set of tests for the Abnormal Involuntary Movement Scale (AIMS) by:

• Training and calibrating raters to ensure accurate, consistent COA administration and scoring
• Conducting site-independent, blinded ratings to assess the change in AIMS score from baseline to week 12 to ensure accuracy

Read our case study for more details.