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Central Rating &
Central Review

Reducing variability with independent expert rating and quality assurance

 
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Signant's Central Expert Services Portfolio

Flexible deployment of independent expert resources tailored to unique individual study requirements

Leverage our global network of 800+ rigorously trained and calibrated expert raters to deliver consistent, independent assessments and real-time quality oversight, reducing variability at its source to optimize your ability to detect meaningful treatment signals.

Central Rating Icon

CENTRAL
RATING

Independent remotely conducted rating interviews and assessments

Eligibility Review Icon

ELIGIBILITY
REVIEW

Comprehensive site-independent assessment of diagnosis and severity to ensure eligibility of enrolled patients

Central Rating Icon

CENTRAL
REVIEW

Expert quality review of clinician rating interviews, with direct rater remediation. Augmented with AI-targeting of rating assessments for expert rater review

Central Scoring Icon

CENTRAL
SCORING

Independent scoring for site-administered assessments

Tandem Rating Icon

TANDEM
RATING

Computerized assessment interview and scoring using a simulated rater

  • Central Rating
  • Eligibility Review
  • Central Review
  • Central Scoring
  • Tandem Rating
  • Central Rating

    Independent remote assessment minimizing inter-rater variability

    Independent experts remotely administer assessments via secure audio/video interviews. Our calibrated raters reduce variability through standardized administration, ensuring assessment consistency and eliminating the potential for functional unblinding.

     

  • Eligibility Review

    Ensuring the correct study population from day one

    Expert reviewers verify diagnosis and disease severity to validate eligibility and limit baseline score inflation. This detailed review ensures study populations accurately reflect protocol criteria to drive optimal signal detection.

     

  • Central Review

    Real-time quality monitoring and remediation for consistent assessments

    Expert reviewers evaluate audio/video recordings of site interviews, identifying administration and scoring errors and inconsistencies. Our experts work directly with sites, providing targeted remediation to improve ongoing endpoint reliability.

    Enhanced with AI-targeted review

    AI-powered tool provides 100% coverage and targets problematic ratings for human verification through expert central review

  • Central Scoring

    Combining in-person clinical examination with standardized expert scoring

    Site raters conduct hands-on assessments while expert central raters provide standardized scoring, ensuring consistent ClinRO scoring

  • Tandem Rating

    Cost-efficient quality control with targeted intervention

    Site assessments are paired with computer-administered interviews for eligibility verification. Discrepancies above thresholds trigger expert review, providing cost-efficient signal detection enhancement.

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Why choose Signant SmartSignals?

Reduce inter-rater variability

Standardized administration and consistent scoring through our calibrated expert network

Prevent inappropriate patient enrollment

Expert eligibility verification ensures correct study populations from day one

Enable proactive and timely remediation

Real-time quality oversight with direct intervention to sites and raters

Ensure protocol compliance

Rigorous adherence of protocol requirements and regulatory standards

Eliminate functional unblinding risk

Independent remote assessments to maintain blinding

Enhance endpoint data quality

Optimized signal detection through reduced variability and improved endpoint reliability

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