Meet the Experts

At Signant Health, we combine our technology with robust clinical, scientific, and regulatory expertise to guide your study from design to regulatory submission, ensuring the generation of clinical evidence of the highest quality and integrity.

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With more than 50 full-time, in-house experts, we are prepared to advise on all areas of eCOA science and best practice including:

  • Study Design
  • eCOA Modality Choice
  • Outcome measure selection
  • Telemedicine Clinician Assessments
  • eCOA Design
  • PRO Dossier Support
  • Rater Training
  • Data Quality Monitoring & Analysis
  • Sensors & Wearable
  • Innovative Technology & Novel Endpoints
Leadership - Dawie

Dawie Wessels, MD

CHIEF MEDICAL OFFICER
David Daniel

DAVID DANIEL, MD

EXECUTIVE ADVISOR, SCHIZOPHRENIA
Gary Sachs

GARY SACHS, MD

CLINICAL VICE PRESIDENT
Joan Busner

JOAN BUSNER, PhD

CLINCIAL VICE PRESIDENT
Lew Fredane

LEW FREDANE, MD

CLINICAL VICE PRESIDENT
David Miller

DAVID MILLER, MD, MA

CLINICAL VICE PRESIDENT
Stephan Bart

STEPHAN BART, SR MD CPI

EXECUTIVE ADVISOR
Alan Kott

ALAN KOTT, MUDr

CLINICAL VICE PRESIDENT & PRACTICE LEAD, DATA ANALYTICS
Todd

TODD EVERHART, MD

CLINICAL VICE PRESIDENT INTERNAL MEDICINE
Bill Byrom

BILL BYROM, PhD

VICE PRESIDENT, PRODUCT INTELLIGENCE & POSITIONING
Elias Ketiar

ELIAS KETIAR, MD, MRCP

CLINICAL VICE PRESIDENT
Greta

GRETA MARIE VAN SCHOOR, PhD

SENIOR CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE
Brandon

BRANDEN KUSANTO, PhD

SENIOR CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE
Lauren

LAUREN CROOKS, MSc

CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE
Viani

VIANI FIGUEROA VAZQUEZ, PhD

CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE
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Leadership - Dawie

Dawie Wessels, MD

CHIEF MEDICAL OFFICER

As Chief Medical Officer of Signant Health, Dawie’s deep expertise across multiple therapeutic areas, multinational development leadership, and experience in associated commercial growth supports the expanding impact of the Signant Science and Medical team. With over twenty years' experience combining medicine and business, Dawie oversees Signant's scientific and operational strategies.

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David Daniel

DAVID DANIEL, MD

EXECUTIVE ADVISOR, SCHIZOPHRENIA

Dr. Daniel has over 25 years of experience overseeing rater training and data quality management programs in various settings. He has supervised countless clinical trials for schizophrenia and bipolar disorder. In addition to his work with Signant, David serves as Clinical Professor of Psychiatry at George Washington University.

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Gary Sachs

GARY SACHS, MD

CLINICAL VICE PRESIDENT

Dr. Sachs is the Therapeutic Area Leader in bipolar disease and mood disorders at Signant. He lends his extensive experience in rater training and the methodologies of mood and anxiety disorder research to support studies. 

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Joan Busner

JOAN BUSNER, PhD

CLINCIAL VICE PRESIDENT

Dr. Busner has over 35 years of experience as an academic psychiatric researcher and psychopharmacology principal investigator, and founded and directed two university psychiatric clinical trials units. Dr. Busner served continuously on University Institutional Review Boards for 20 years. At Signant she has scientific and clinical responsibility for studies in mood, anxiety, pediatrics, and rare/orphan diseases.

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Lew Fredane

LEW FREDANE, MD

CLINICAL VICE PRESIDENT

Dr. Fredane serves as the Therapeutic Area Leader for neurology, overseeing Signant’s eCOA, rater training, and quality assurance work. He has experience as a practicing neurologist, clinical assistant professor, and in the drug development for over 15 years.

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David Miller

DAVID MILLER, MD, MA

CLINICAL VICE PRESIDENT

Dr. Miller is a geriatric psychiatrist by training. He has over 25 years of experience in patient care, clinical research, teaching, and even served as a principal investigator for dementia studies. David currently serves as the Chair of the Alzheimer’s Association Research Roundtable.

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Stephan Bart

STEPHAN BART, SR MD CPI

EXECUTIVE ADVISOR

Dr. Bart is both Board certified and a Certified Physician Investigator with a broad therapeutic scope including successful completion of more than 450 domestic and international phase 1 through 3 human clinical trials. He has maintained a successful private practice, held faculty positions at Penn State University and the University of Maryland Medical Center, as well as published many articles in prestigious peer reviewed journals. 

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Alan Kott

ALAN KOTT, MUDr

CLINICAL VICE PRESIDENT & PRACTICE LEAD, DATA ANALYTICS

Dr. Kott is based in Signant’s Prague office and until recently was Senior Clinical Manager for Europe. Having led the development of the Data Analytics Program for Bracket, he has overseen the design and reporting of data analytics in multiple large schizophrenia studies. For the past seven years, he has also provided training to investigators as an Expert Trainer.

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Todd

TODD EVERHART, MD

CLINICAL VICE PRESIDENT INTERNAL MEDICINE

Dr. Everhart is an innovator, educator, and leader in the pharmaceutical and biotechnology industries with over 25 years of experience in the practice of medicine and over 14 years of experience in clinical research.  Board-certified in Internal Medicine and a Fellow of the American College of Physicians, he is one of Signant Health’s experts in decentralized trials, rater training, blinded data analytics, and placebo response mitigation.

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Bill Byrom

BILL BYROM, PhD

VICE PRESIDENT, PRODUCT INTELLIGENCE & POSITIONING

Dr. Byrom has worked in the pharmaceutical industry for 30 years. He has authored over 70 publications and two industry textbooks on electronic patient-reported outcomes (ePRO). His recent scientific work includes the use of wearable technology and bring-your-own-device (BYOD) eCOA in clinical trials.

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Elias Ketiar

ELIAS KETIAR, MD, MRCP

CLINICAL VICE PRESIDENT

Dr. Elias Ketiar serves as the Clinical Vice President, Science & Medicine, at Signant Health. Dr. Ketiar draws on his wealth of more than 20 years of academic and clinical experience to advise on clinical trial design, execution, and governance.

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Greta

GRETA MARIE VAN SCHOOR, PhD

SENIOR CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE

Greta is a Senior Clinical Scientist, providing scientific expertise and guidance relating to the implementation of electronic clinical outcome assessments (eCOAs), with a special focus on eDiary design and accessibility of eCOA best practices. She completed her PhD in Physiological Sciences at Stellenbosch University, which focused on the bacterial and inflammatory involvement in colorectal carcinogenesis, and has 3+ years’ experience in the clinical research industry.

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Brandon

BRANDEN KUSANTO, PhD

SENIOR CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE

Dr. Kusanto studied bioengineering at Oregon State University before completing his PhD in platelet biology at Hull York Medical School. At Signant, he specializes in eCOA, eConsent, and multiple therapeutic areas like, dermatology, gastroenterology, pediatrics, and rare diseases.

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Lauren

LAUREN CROOKS, MSc

CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE

Lauren has comprehensive cross-functional experience within the life sciences and information technology sectors. At Signant, she combines this experience to provide scientific consultation and support to clients on the implementation of eCOA to optimize patient care and outcomes in clinical trials. She has supported eCOA projects across multiple therapeutic areas, including dermatology and neurology, with a current focus on respiratory diseases.

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Viani

VIANI FIGUEROA VAZQUEZ, PhD

CLINICAL SCIENTIST, DIGITAL HEALTH & eCOA SCIENCE

Dr. Figueroa is a Clinical Scientist with the eCOA Science Team, where she leverages her extensive expertise in electronic Clinical Outcome Assessments (eCOA) across diverse therapeutic areas, including oncology, dermatology, and infectious diseases. With over a decade of translational research experience, Dr. Figueroa is dedicated to advancing the field of clinical trials and improving patient outcomes through innovative methodologies and strategic insights.

Want to learn more?

Contact us today to engage with our experts and optimize your study's journey from design through regulatory submission, ensuring the highest standards of clinical evidence generation