Leveraging Ecological Momentary Assessment in Depression Trials

In a 6-week trial, 36 participants with major depressive disorder (MDD) used ecological momentary assessment (EMA) to self-report symptoms twice daily. Strong correlations between EMA-derived HamD6 scores and clinician ratings were found, with EMA showing significant improvements over time. Treatment responses from EMA matched clinician ratings in 91.7% of cases. These findings suggest that EMA can provide more accurate, daily tracking of depression symptoms, offering a promising alternative to traditional assessments in clinical trials.