Introducing Signant Health

Take a significant step towards patient-centricity

We help you connect patients and researchers to ensure data reliability, with proven solutions that simplify every step of the patient journey. Our deep therapeutic area expertise, agile technology and service scale enable us to minimize risk, innovate, and support your important work. We seek speed, efficiency and reduced variability to help you extend the reach of drug development, expand patient opportunities and improve data quality helping you bring life-changing therapies to our families and communities around the world.


“We put patients at the center of clinical research. From eCOA, eConsent and Patient Engagement to Endpoint Quality and Clinical Supplies, we simplify their journey through clinical trials and simplify the work of the study teams and sites that support them. Built on technology with the power to move research more quickly and more precisely, we make it easier for you to change lives.”- Mike Nolte, CEO of Signant Health

Our History


CRF Bracket re-emerges as Signant Health, a unified patient technology organization focused on making it easier for sponsors and CROs to change lives.


The combined CRF Bracket grows more in 1st quarter together than either company achieved alone in 2018.


Genstar Capital acquired CRF Health and combined it with Bracket to become CRF Bracket and deliver industry-leading patient-centric technology to improve the speed, reliability and insight of clinical research.


Bracket releases CUBE™, a transformative interactive response technology (IRT) solution for the life sciences industry.


Bracket Acquires mProve Health to radically advance patient engagement in clinical trials


CRF Health achieves one million monthly patient interactions.


Bracket was created in 2011 through the merger of the Specialty Clinical Services and Clinical Technologies Group business units within United BioSource Corporation (UBC).


PharmaStar LLC, the predecessor to Bracket Global LLC, was founded.


CRF Health, formerly known as CRF Inc., was founded.